There are no specific articles on the use of oxygen therapy in periventricular leukomalacia. However recovery of PVL induced by the omission of filtration in cardiac sugery has been documented.
Muraoka R, Yokota M, Aoshima M, Kyoku I, Nomoto S, Kobayashi A, Nakano
H, Ueda K, Saito A, Hojo H.
Subclinical changes in brain morphology following cardiac operations as reflected by computed tomographic scans of the brain. J Thorac Cardiovasc Surg 1981;81:364-69.
The widening of the ventricles was followed by CT in children after cardiac surgery without filtration for microemboli. However the loss on midbrain volume (widening of the ventricles) was not permanent. This recovery occurred breathing air - in other words there was sufficient oxygen in the air to allow recovery. Where the tissue process causes swelling it prevents sufficient oxygen reaching the tissue and recovery may not take place breathing air. It is then necessary to increase the amount of oxygen in the gas breathed - which this may require a pressure chamber. However the extent to which recovery can take place depends upon the extent of the damage and at the present time we do not have the technology to accurately determine how much recovery can take place. It can bedetermined by the response to treatment.
Wolfson Hyperbaric Medicine Unit
University of Dundee